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GLPG0634 analogue
CAS No. 1206101-20-3
GLPG0634 analogue( Filgotinib-analogue, GLPG0634-analogue )
Catalog No. M17191 CAS No. 1206101-20-3
GLPG0634 (analog) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 43 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 249 | In Stock |
|
| 50MG | 441 | In Stock |
|
| 100MG | 624 | In Stock |
|
| 500MG | 1305 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGLPG0634 analogue
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NoteResearch use only, not for human use.
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Brief DescriptionGLPG0634 (analog) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
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DescriptionGLPG0634-analogue is an analogue of Filgotinib or GLPG0634, is a potent and selective JAK1 inhibitor.
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In VitroGLPG0634 analog (Compoun 176) inhibits JAK-STAT signaling and OSM/IL-lβ signaling with both EC50 values of 101-500 nM.GLPG0634 analog shows microsomal stability of 76%-100% in rat and human.
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In Vivo——
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SynonymsFilgotinib-analogue, GLPG0634-analogue
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PathwayNeuroscience
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TargetGluR
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RecptorJAK1| JAK2| JAK3
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1206101-20-3
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Formula Weight425.5
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Molecular FormulaC21H23N5O3S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 53 mg/mL 129.13 mM
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SMILESO=C(C1CC1)Nc1nn2c(c3ccc(OCc4ccc(C#N)nc4)cc3)cccc2n1
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Chemical NameN-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Van Rompaey L, et al. J Immunol. 2013, 191(7), 3568-3577.
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